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Polydopamine-assisted one-step modification of nanofiber surfaces with adenosine to tune the osteogenic differentiation of mesenchymal stem cells and the maturation of osteoclasts

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM01990A, Paper
Taufiq Ahmad, Hayeon Byun, Hyeok Jun Shin, Jinkyu Lee, Sajeesh Kumar Madhurakkat Perikamana, Eun Mi Kim, Young Min Shin, Heungsoo Shin
Adenosine and its receptors have emerged as alternative targets to control cellular functions for bone healing.
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Correction: An eximious and affordable GSH stimulus-responsive poly(α-lipoic acid) nanocarrier bonding combretastatin A4 for tumor therapy

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM90037K, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Zhilin Liu, Na Shen, Zhaohui Tang, Dawei Zhang, Lili Ma, Chenguang Yang, Xuesi Chen
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Fixed-point “blasting” triggered by second near-infrared window light for augmented interventional photothermal therapy

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00372G, Paper
Yongbin Cao, Boshu Ouyang, Xiaowei Yang, Qin Jiang, Lin Yu, Shun Shen, Jiandong Ding, Wuli Yang
Tumors were effectively destroyed by a mild photothermal effect and the subsequent gas mechanical damage triggered by NIR-II light.
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Development of new self-assembled cationic amino liposomes for efficient gene delivery

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00331J, Communication
Yihang Wu, Yue Xiong, Ling Wang, Quanming Zhou, Linxian Li, Pavel A. Levkin, Gary Davidson, Liqian Gao, Wenbin Deng
A library of lipidoids self-assembling to liposomes exhibits excellent transfection efficiency in HEK 293T cells and mESCs with low cytotoxicity.
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Matrix stiffness-regulated cellular functions under different dimensionalities

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM01809C, Review Article
Jiajun Zhong, Yuexiong Yang, Liqiong Liao, Chao Zhang
The microenvironments that cells encounter with in vitro.
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Delivery of dual miRNA through CD44-targeted mesoporous silica nanoparticles for enhanced and effective triple-negative breast cancer therapy

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00015A, Paper
Manisha Ahir, Priyanka Upadhyay, Avijit Ghosh, Sushmita Sarker, Saurav Bhattacharya, Payal Gupta, Swatilekha Ghosh, Sreya Chattopadhyay, Arghya Adhikary
Cationic Mesoporous silica Nanoparticle coated with hyaluronic acid conjugated polymer (HA-Dual miRNA Np) facilitated enhanced dual miRNA loading, efficient delivery and significantly inhibited tumor growth as well as retarded metastasis in triple-negative breast cancer.
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In situ preparation of gold–polyester nanoparticles for biomedical imaging

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00175A, Paper
Mohamed F. Attia, Meenakshi Ranasinghe, Roman Akasov, Jeffrey N. Anker, Daniel C. Whitehead, Frank Alexis
Hybrid gold-polyester nanoparticles were synthesized by UV irradiation of a gold salt and photoinitiator encapsulated in a polyester nanoparticle. The resulting materials exhibit excellent cellular imaging and surface plasmon resonance properties.
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Bacterial nanocellulose as a corneal bandage material: a comparison with amniotic membrane

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00083C, Paper
Open Access
Irene Anton-Sales, Justin Christopher D'Antin, Jorge Fernández-Engroba, Victor Charoenrook, Anna Laromaine, Anna Roig, Ralph Michael
Bacterial nanocellulose exhibits valuable properties to act as a corneal bandage material in terms of conformability, suturability, durability and ease of manipulation in ophthalmological environments.
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Nanozyme-catalyzed oxygen release from calcium peroxide nanoparticles for accelerated hypoxia relief and image-guided super-efficient photodynamic therapy

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00187B, Paper
Yuping Hu, Xuechun Wang, Peng Zhao, Hao Wang, Wei Gu, Ling Ye
The accelerated O2 release from CaO2 catalyzed by MnO2 nanozyme leads to a rapid and efficient hypoxia relief, an increased yield of 1O2, a down-regulated HIF-1α and VEGF, and eventually a super-efficient PDT.
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Arbitrarily-shaped microgels composed of chemically unmodified biopolymers

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM02056J, Paper
Yadu N. Vakkipurath Kodakkadan, Kristyna Idzakovicova, Josef Sepitka, Daniël ten Napel, Eric Safai, Petr Cigler, Frantisek Štěpánek, Ivan Rehor
We introduce a method for photolithographic synthesis of arbitrarily shaped microgels composed purely of a biopolymer of choice.
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High antimicrobial photodynamic activity of photosensitizer encapsulated dual-functional metallocatanionic vesicles against drug-resistant bacteria S. aureus

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00323A, Paper
Bunty Sharma, Gurpreet Kaur, Ganga Ram Chaudhary, Santosh L. Gawali, P. A. Hassan
Developments in the field of photodynamic therapy (PDT) are being made by investigating appropriate photosensitizers (PSs) and enhancing the penetration effect of light by developing new metallocatanionic vesicles.
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Influence of the mechanical properties of biomaterials on degradability, cell behaviors and signaling pathways: current progress and challenges

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00269K, Review Article
Lu Wang, Cunyang Wang, Shuai Wu, Yubo Fan, Xiaoming Li
We have clarified the influence of the mechanical properties of biomaterials on degradability and cell response, and also mechanical design targets and approaches.
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A bioartificial liver support system integrated with a DLM/GelMA-based bioengineered whole liver for prevention of hepatic encephalopathy via enhanced ammonia reduction

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM01879D, Paper
Guohua Wu, Di Wu, James Lo, Yimin Wang, Jianguo Wu, Siming Lu, Han Xu, Xin Zhao, Yong He, Jun Li, Utkan Demirci, Shuqi Wang
The developed bioartificial liver support system integrated with the decellularized liver matrix/GelMA-based bioengineered whole liver can potentially help elevate liver functions and prevent hepatic encephalopathy via enhanced ammonia reduction.
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Osteopromotive carbon dots promote bone regeneration through the PERK-eIF2α-ATF4 pathway

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00424C, Paper
Nianqiang Jin, Nuo Jin, Zilin Wang, Lili Liu, Lin Meng, Daowei Li, Xing Li, Dabo Zhou, Jie Liu, Wenhuan Bu, Hongchen Sun, Bai Yang
Novel carbon dots induced ER stress and activated PERK-eIF2α-ATF4 pathway promote bone regeneration.
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Strategic reconstruction of macrophage-derived extracellular vesicles as a magnetic resonance imaging contrast agent

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00128G, Paper
Sagar Rayamajhi, Ramesh Marasini, Tuyen Duong Thanh Nguyen, Brandon L. Plattner, David Biller, Santosh Aryal
Reconstruction of extracellular vesicles with imaging agents allows precise downstream analysis using clinical imaging modalities, for example, MRI. This will further improve the biocompatibility of agents thereby enhancing clinical investigations.
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Balancing the thickness of sensitizing and inert layers in neodymium-sensitized tetralayer nanoconstructs for optimal ultraviolet upconversion and near-infrared cross-linked hydrogel tissue sealants

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00453G, Paper
Zhongzheng Yu, Yong Yao Chun, Jingwen Xue, Jodie Zu Yi Tan, Wen Kiat Chan, Weizheng Cai, Yan Zhang, Timothy Thatt Yang Tan
Balancing the thickness of sensitizing and inert layers in neodymium-sensitized tetralayer nanoconstructs for optimal ultraviolet upconversion.
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Cu, Zn doped borate bioactive glasses: antibacterial efficacy and dose-dependent in vitro modulation of murine dendritic cells

Biomater. Sci., 2020, 8,2143-2155
DOI: 10.1039/C9BM01691K, Paper
Open Access
Katharina Schuhladen, Lena Stich, Jochen Schmidt, Alexander Steinkasserer, Aldo R. Boccaccini, Elisabeth Zinser
Bioactive borate glasses additionally doped with copper and/or zinc have enthralling immune-modulatory effects on immune cells.
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A fluorinated low-molecular-weight PEI/HIF-1α shRNA polyplex system for hemangioma therapy

Biomater. Sci., 2020, 8,2129-2142
DOI: 10.1039/D0BM00171F, Paper
Xiaoshuang Guo, Zihan Yuan, Yang Xu, Minyan Wei, Zhiwei Fang, Wei-En Yuan
RNAi technology targeting HIF-1α could benefit hemangioma therapy effectively and FPEI polyplexes which could inhibit the expression of HIF-1α at the translational level can provide a practicable strategy for clinical hemangioma treatment in the future.
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Methylcellulose – a versatile printing material that enables biofabrication of tissue equivalents with high shape fidelity

Biomater. Sci., 2020, 8,2102-2110
DOI: 10.1039/D0BM00027B, Minireview
Open Access
T. Ahlfeld, V. Guduric, S. Duin, A. R. Akkineni, K. Schütz, D. Kilian, J. Emmermacher, N. Cubo-Mateo, S. Dani, M. v. Witzleben, J. Spangenberg, R. Abdelgaber, R. F. Richter, A. Lode, M. Gelinsky
This minireview highlights the use of the polysaccharide methylcellulose for biofabrication applications. Its properties are useful for printing of dissolvable support structures as well as the development of novel bioinks.
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Amino-containing tannic acid derivative-mediated universal coatings for multifunctional surface modification

Biomater. Sci., 2020, 8,2120-2128
DOI: 10.1039/D0BM00242A, Paper
Yan Fang Cheng, Dicky Pranantyo, Gopinath Kasi, Zhi Song Lu, Chang Ming Li, Li Qun Xu
An amino-containing tannic acid derivative was self-polymerized to form colorless and uniform coatings on various substrate surfaces, and the resultant coatings can be further utilized to construct bioactive, antifouling and antibacterial surfaces.
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Sulfur dioxide signaling molecule-responsive polymeric nanoparticles

Biomater. Sci., 2020, 8,2300-2307
DOI: 10.1039/D0BM00276C, Paper
Ruru Li, Xiaoyu Huang, Guolin Lu, Chun Feng
A PEG45-b-PVPOP14 diblock copolymer with pendant levulinate-protected phenol groups exhibited a highly specific response toward sulfites.
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Hydrophilic titanium surfaces reduce neutrophil inflammatory response and NETosis

Biomater. Sci., 2020, 8,2289-2299
DOI: 10.1039/C9BM01474H, Paper
Open Access
Jefferson O. Abaricia, Arth H. Shah, Ryan M. Musselman, Rene Olivares-Navarrete
Neutrophils are sensitive to biomaterial surface properties, controlling activation and inflammatory microenvironment, revealing a novel target for enhancing biomaterial integration.
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Stabilization of indocyanine green dye in polymeric micelles for NIR-II fluorescence imaging and cancer treatment

Biomater. Sci., 2020, 8,2245-2254
DOI: 10.1039/C9BM02010A, Paper
Gil Yeroslavsky, Masakazu Umezawa, Kyohei Okubo, Karina Nigoghossian, Doan Thi Kim Dung, Keiji Miyata, Masao Kamimura, Kohei Soga
Encapsulation of ICG and IR-1061 in PCL–PEG micelles producing agents with increased stability of ICG and tunable PTT and PDT activity. The micelles are also useful for NIR imaging and NIR nanothermometry.
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From single to a dual-gene delivery nanosystem: coordinated expression matters for boosting the neovascularization in vivo

Biomater. Sci., 2020, 8,2318-2328
DOI: 10.1039/C9BM02000D, Paper
Bin Gao, Xiaoyu Wang, Meiyu Wang, Xiang-kui Ren, Jintang Guo, Shihai Xia, Wencheng Zhang, Yakai Feng
A dual-gene delivery system with coordinated expression function boosted the neovascularization.
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MT1-MMP activatable fluorogenic probes with enhanced specificity via high-affinity peptide conjugation for tumor imaging

Biomater. Sci., 2020, 8,2308-2317
DOI: 10.1039/C9BM02007A, Paper
Xiuru Ji, Shuping Xie, Yan Jiao, Xiaojuan Zhang, Duxin Sun, Victor C. Yang, Mei Wang, Huining He, Lu Sun
A novel MT1-MMP activatable fluorogenic probe for tumor detection with enhanced specificity was developed via high-affinity and specific peptide conjugation.
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The use of auxetic materials in tissue engineering

Biomater. Sci., 2020, 8,2074-2083
DOI: 10.1039/C9BM01928F, Review Article
Paul Mardling, Andrew Alderson, Nicola Jordan-Mahy, Christine Lyn Le Maitre
A number of biological tissues have been shown to behave in an auxetic manner, defined by having a negative poissons ratio. Thus mimicking this environment has a number of potential applications especially in tissue engineering.
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An acoustic/thermo-responsive hybrid system for advanced doxorubicin delivery in tumor treatment

Biomater. Sci., 2020, 8,2202-2211
DOI: 10.1039/C9BM01794A, Paper
Li Zhang, Shiyu Zhang, Huajian Chen, Yu Liang, Bingxia Zhao, Wanxian Luo, Qian Xiao, Jinheng Li, Junqiao Zhu, Chao Peng, Yaru Zhang, Zhe Hong, Ying Wang, Yingjia Li
Ultrasound-assisted fast extravasation and the following laser-triggered drug release of thermo-sensitive liposomes synergistically enhanced drug delivery in deep tumors.
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Two-step tumor-targeting therapy via integrating metabolic lipid-engineering with in situ click chemistry

Biomater. Sci., 2020, 8,2283-2288
DOI: 10.1039/D0BM00088D, Paper
Guihong Lu, Liping Zuo, Jinfeng Zhang, Houshun Zhu, Wanru Zhuang, Wei Wei, Hai-Yan Xie
A highly efficient two-step targeting strategy integrating metabolic lipid-engineering with in situ click chemistry is developed, thus significantly improved the tumor theranostic performance of the red blood cells ghosts based drug delivery.
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Ultra pH-sensitive polymeric nanovesicles co-deliver doxorubicin and navitoclax for synergetic therapy of endometrial carcinoma

Biomater. Sci., 2020, 8,2264-2273
DOI: 10.1039/D0BM00112K, Paper
Jie Ding, Xu Zhang, Chuangqi Chen, Yuqiang Huang, Xingsu Yu, Xiaomao Li
An ultra pH-sensitive polymeric nanovesicle was constructed to co-deliver doxorubicin and navitoclax for highly efficient synergetic treatment of endometrial carcinoma.
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Tumor-targeting peptide functionalized PEG-PLA micelles for efficient drug delivery

Biomater. Sci., 2020, 8,2274-2282
DOI: 10.1039/C9BM02036E, Paper
Yue Cai, Zhuomin Xu, Qi Shuai, Fangtao Zhu, Jiao Xu, Xin Gao, Xuanrong Sun
PEG-PLA micelles are modified with F3 peptides, thus endowing the micelles with active-targeting ability due to the nucleolin-binding ability of the F3 peptides.
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A polymeric nanocarrier with a tumor acidity-activatable arginine-rich (R9) peptide for enhanced drug delivery

Biomater. Sci., 2020, 8,2255-2263
DOI: 10.1039/D0BM00069H, Paper
Liting Zhang, Chengtao Jiang, Fanjun Zeng, Haiyu Zhou, Dongdong Li, Xinyu He, Song Shen, Xianzhu Yang, Jun Wang
The cell-penetrating function of R9 peptide of DA@R9-NPDOX was masked in the blood circulation, while reactivated in tumor tissue for enhanced tumor cellular uptake.
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A biodegradable CO2-based polymeric antitumor nanodrug via a one-pot surfactant- and solvent-free miniemulsion preparation

Biomater. Sci., 2020, 8,2234-2244
DOI: 10.1039/C9BM01931F, Paper
Qiaojie Luo, Xiaojun Li, Ying Wang, Jianfang He, Qiao Zhang, Pengfei Ge, Xia Cai, Qiang Sun, Weipu Zhu, Zhiquan Shen, Xiaodong Li
A biodegradable CO2-based polymeric nanodrug is obtained via a surfactant- and solvent-free miniemulsion preparation, which can be concentrated at tumor site by EPR and releases the encapsulated drug through pH responsiveness.
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RSC - Mol. BioSyst. latest articles


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FSIS Issues Public Health Alert for Chicken Noodle Soup Products Due to Misbranding and an Undeclared Allergen

The U.S. Department of Agriculture’s Food Safety and Inspection Service (FSIS) is issuing a public health alert due to illnesses caused by Listeria monocytogenes associated with FDA-regulated hard boiled eggs that have been recalled by Almark Foods.


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CDC/DOL Issues Guidance to Industry

The Centers for Disease Control and Prevention (CDC) and the Department of Labor (DOL) have issued guidance specific to the meat and poultry processing industry in order to facilitate ongoing operations and support the food supply, while also mitigating the risk of spreading COVID-19.


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Jowett Farms Corporation Recalls Pork Products Produced without Benefit of Import Inspection

Jowett Farms Corporation, a Blumenort, Canada establishment, is recalling approximately 42,587 pounds of raw pork trimmings that were not presented for import re-inspection into the United States, the U.S. Department of Agriculture’s Food Safety and Inspection Service (FSIS) announced today.


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Conagra Brands, Inc. Recalls Frozen Not-Ready-to-Eat Chicken Bowl Products Due to Possible Foreign Matter Contamination

Conagra Brands, Inc., a Russellville, Ark. establishment, is recalling approximately 130,763 pounds of not ready-to-eat chicken bowl products because the product may contain extraneous material, specifically small rocks.


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USDA Ensures Food Safety During COVID-19 Outbreak

The U.S. Department of Agriculture (USDA) is ensuring the safety and timely delivery of the U.S. food supply while protecting the health of USDA employees during this COVID-19 National Emergency. Yesterday, USDA Under Secretary for Marketing and Regulatory Programs Greg Ibach and USDA Deputy Under Secretary for Food Safety Dr. Mindy Brashears sent a letter to stakeholders reassuring them that APHIS, AMS, and FSIS are rising to meet the challenges associated with COVID-19.


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Statement to Industry

The U.S. Department of Agriculture is rising to meet the challenges associated with the new coronavirus disease, Covid-19. As leaders of USDA’s Food Safety and Inspection Service, Animal and Plant Health Inspection Service and Agricultural Marketing Service, we can assure you that the agencies are committed to ensuring the health and safety of our employees while still providing the timely delivery of the services to maintain the movement of America’s food supply from farm to fork.


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Secretary Perdue Announces New FSIS Leadership

U.S. Secretary of Agriculture Sonny Perdue today announced the appointment of Paul Kiecker to serve as Administrator of the U.S. Department of Agriculture’s (USDA) Food Safety and Inspection Service (FSIS). Mr. Kiecker will be assuming the role following the departure of Administrator Carmen Rottenberg, who is departing federal service after a career spanning two decades.


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Family Traditions Meat Company Recalls Ready-to-Eat Meat Stick Products Due to Misbranding and an Undeclared Allergen

Family Traditions Meat Company, an Ackley, Iowa establishment, is recalling approximately 270 pounds of ready-to-eat (RTE) beef stick products due to misbranding and an undeclared allergen.


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This Super Bowl, Don’t Get Sacked by Foodborne Illness

According to the National Chicken Council, Americans will consume more than 1.4 billion chicken wings this Super Bowl Sunday. Add to that countless slices of pizza and other munchies, and you’ll have a recipe for a winning Super Bowl party. But if you’re not careful, you could be putting your guests at risk for foodborne illness. Follow the U.S. Department of Agriculture’s (USDA) Food Safety and Inspection Service’s (FSIS) game plan to avoid getting sick this Super Bowl Sunday.


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Astrochef LLC. Recalls Pepperoni Stuffed Pizza Sandwich Products due to Misbranding and Undeclared Allergens

Astrochef LLC., a Rockwall, Texas establishment, is recalling approximately 7,363 pounds of pepperoni stuffed pizza sandwich products because the product is mislabeled and contains undeclared soy, a known allergen.


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Golden Pearl Trading Corporation Recalls Ready to Eat Imported Siluriformes Products Produced Without Benefit of Import Inspection

Golden Pearl Trading Corporation (doing business as Dandy Food Products), a San Lorenzo, Calif. establishment, is recalling approximately 12,054 pounds of ready-to-eat (RTE) imported Siluriformes products that were not presented for import re-inspection into the United States.


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Amity Packing Company Inc. Recalls Raw Ground Beef Products Due to Possible Foreign Matter Contamination

Amity Packing Company Inc., a Chicago, Ill. establishment, is recalling approximately 2,020 pounds of raw ground beef products that may be contaminated with extraneous materials, specifically clear, thin pliable plastic.


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Culinary International, LLC Recalls Chicken Burrito Products Due to Misbranding and Undeclared Allergens

Culinary International, LLC, a Vernon, Calif. establishment, is recalling approximately 626 pounds of egg burrito products labeled as chicken burrito products due to misbranding and undeclared allergens.


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FSIS Issues Public Health Alert for Swedish Meatball Products Due to Misbranding and an Undeclared Allergen

The U.S. Department of Agriculture’s Food Safety and Inspection Service (FSIS) is issuing a public health alert because Carso’s Pasta Company, a Lynnwood, Wash. establishment, sold 636 pounds of ready-to-eat (RTE) Swedish meatball products that were misbranded. The products contain anchovies (fish), which are not declared on the product label. A recall was not requested because it is believed that the products are no longer available for consumers to purchase.


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Kettle Cuisine Midco, LLC, Recalls Ready-To-Eat Soup Products due to Misbranding and Undeclared Allergens

Kettle Cuisine Midco, LLC, a Lynn, Mass. establishment, is recalling approximately 200 pounds of ready-to-eat (RTE) lentil and beef soup products due to misbranding and undeclared allergens.


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FSIS Issues Public Health Alert for Products Associated with the FDA Almark Foods Recall Due to Possible Listeria Monocytogenes Contamination

The U.S. Department of Agriculture’s Food Safety and Inspection Service (FSIS) is issuing a public health alert due to illnesses caused by Listeria monocytogenes associated with FDA-regulated hard boiled eggs that have been recalled by Almark Foods.


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J&J Distributing Recalls Salad Products Due to Misbranding and Undeclared Allergens

J&J Distributing, a St. Paul, Minn. establishment, is recalling approximately 136 pounds of ready-to-eat salad products that contain meat due to misbranding and undeclared allergens.


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