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A highly efficient preconcentration route for rapid and sensitive detection of endotoxin based on an electrochemical biosensor

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00315H, Paper
Wenrui Ma, Lulu Liu, Yi Xu, Li Wang, Li Chen, Sheng Yan, Lingling Shui, Zhijun Wang, Shunbo Li
An impedimetric aptasensor for detection of endotoxin in a microfluidic chip was proposed, in which the Apt/AuNPs/SPCE sensing surface was fabricated in screen-printed electrode with good biological activity and stability....
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Quantitative toxicological study of dose-dependent arsenic-induced cells via synchrotron-based STXM and FTIR measurement

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00346H, Paper
Huiqiang Liu, Junshan Xiu, Yunyan Liu, Bengyi Wang, Yanling Xue, Min Chen, Te Ji
Inorganic arsenic (iAs) is a well-known naturally occurring metalloid with abundant hazards in our environment, especially being a human carcinogen through arsenic contaminated drinking water. The iAs-related contamination is usually...
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Recent advances in nanomaterial-enhanced enzyme-linked immunosorbent assays

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00597E, Critical Review
Lu Gao, Qianfan Yang, Peng Wu, Feng Li
Despite serving as a gold standard for protein analysis, the classic enzyme-linked immunosorbent assay (ELISA) is currently challenged by the ever-increasing needs of sensitivity and simplicity. Towards the ongoing needs,...
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Selective ratiometric red-emission detection of In3+ in aqueous solutions and in live cells using a fluorescent peptidyl probe and metal chelating agent

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00288G, Paper
Joohee Park, Hyeongseok Yu, See-Hyoung Park, Keun-Hyeung Lee
A ratiometric fluorescent detection method for In3+ in aqueous buffered solution, ground water, and live cells was developed.
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Direct embedding and versatile placement of electrodes in 3D printed microfluidic-devices

Analyst, 2020, 145,3274-3282
DOI: 10.1039/D0AN00240B, Paper
Andre D. Castiaux, Emily R. Currens, R. Scott Martin
In this paper, we describe how PolyJet 3D printing technology can be used to fully integrate electrode materials into microfluidic devices during the print process.
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Detection and classification of fentanyl and its precursors by surface-enhanced Raman spectroscopy

Analyst, 2020, 145,3440-3446
DOI: 10.1039/C9AN02568E, Paper
Rustin Mirsafavi, Martin Moskovits, Carl Meinhart
An analytical technique combining partial least squares-discriminant analysis, surface-enhanced Raman spectroscopy (SERS), and microfluidics for the detection and classification of fentanyl and its chemical precursors.
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Development of a chromophore-solid phase peptide reaction assay (C-SPRA) for assessing skin sensitization in vitro

Analyst, 2020, 145,3211-3216
DOI: 10.1039/C9AN02514F, Communication
Hiroshi Miyazaki, Yoshio Hamada, Hikaru Takaishi, Yuuki Minamino, Hidefumi Ikeda, Hideaki Mekata, Masayuki Takaishi, Kunihiko Yamashita, Kenji Usui
We developed an in vitro chromophore-solid phase peptide reaction assay (C-SPRA) using chromophores and immobilized peptides on microbeads. C-SPRA would enable accurate and high-throughput assessments of various chemicals.
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Removing interference-based effects from infrared spectra – interference fringes re-revisited

Analyst, 2020, 145,3385-3394
DOI: 10.1039/D0AN00062K, Paper
Thomas G. Mayerhöfer, Susanne Pahlow, Uwe Hübner, Jürgen Popp
Substantial refractive index mismatches between substrate and layers lead to undulating baselines and changes of band intensity, shape and position. For proper spectrum interpretation, all of these effects must be removed.
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The fingerprint of essential bio-oils by Fourier transform ion cyclotron resonance mass spectrometry

Analyst, 2020, 145,3414-3423
DOI: 10.1039/C9AN02492A, Paper
Claudia X. Ramírez, Diana Catalina Palacio Lozano, Hugh E. Jones, Rafael Cabanzo Hernández, Mark P. Barrow, Enrique Mejia-Ospino
Six essential oils were analyzed by Fourier transform ion cyclotron resonance mass spectrometry coupled to negative electrospray ionization (ESI(–)/FT-ICR MS).
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Nano-crystalline cellulose-coated magnetic nanoparticles for affinity adsorption of glycoproteins

Analyst, 2020, 145,3407-3413
DOI: 10.1039/D0AN00442A, Paper
Jiaying Zhang, Xiangyu Feng, Jing Wang, Guozhen Fang, Jifeng Liu, Shuo Wang
A new core–shell structured nanomaterial based on Fe3O4 nanoparticles and 2,3-dialdehyde nanocrystalline cellulose (DAC) coatings and its high efficiency in the preconcentration of glycoproteins were described in this work.
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Synthesis of a manganese dioxide nanorod-anchored graphene oxide composite for highly sensitive electrochemical sensing of dopamine

Analyst, 2020, 145,3283-3288
DOI: 10.1039/D0AN00348D, Paper
Juan Li, Huifang Shen, Suhua Yu, Geshan Zhang, Chuanli Ren, Xiaoya Hu, Zhanjun Yang
A novel manganese dioxide nanorod-anchored graphene oxide (MnO2 NRs/GO) composite was synthesized by a simple hydrothermal method for the development of a highly sensitive electrochemical sensor for dopamine.
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Colorimetric identification of lanthanide ions based on two carboxylic acids as an artificial tongue

Analyst, 2020, 145,3359-3363
DOI: 10.1039/D0AN00357C, Paper
Chi Zhang, Juan Huang, Wei Wei, Zhengbo Chen
We report a colorimetric array, which consists of two carboxylic acids (quinolinic acid (QA), tannic acid (TCA)) as the sensor element and Eriochrome Black T (EBT) as the colorimetric signal readout.
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Rapid detection of 21 β-lactams using an immunochromatographic assay based on the mutant BlaR-CTD protein from Bacillus Licheniformis

Analyst, 2020, 145,3257-3265
DOI: 10.1039/D0AN00421A, Paper
Yue Li, Xinxin Xu, Liqiang Liu, Hua Kuang, Liguang Xu, Chuanlai Xu
In this study, a gold immunochromatographic assay (GICA) based on a penicillin receptor protein (PBP) is proposed to simultaneously detect penicillin, cephalosporin, and carbapenem antibiotics in milk and chicken.
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Using the interfacial barrier effects of p–n junction on electrochemistry for detection of phosphate

Analyst, 2020, 145,3217-3221
DOI: 10.1039/C9AN02579K, Communication
Yu Ding, Minggang Zhao, Jiatuo Yu, Xiaomin Zhang, Zhengming Li, Hui Li
The electrochemical response to phosphate was produced by the induced change of the interfacial barrier of the NiO/ZnO p–n junction foam.
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Novel ratiometric electrochemical sensor for no-wash detection of fluorene-9-bisphenol based on combining CoN nanoarrays with molecularly imprinted polymers

Analyst, 2020, 145,3320-3328
DOI: 10.1039/D0AN00345J, Paper
Zhaoyi Liu, Yong Zhang, Bing Li, Xiang Ren, Hongmin Ma, Qin Wei
A ratiometric molecularly imprinted polymers electrochemical sensor was fabricated based on the direct electrochemical oxidation of BHPF on CoN nanoarray electrode.
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In situ multiplex detection of serum exosomal microRNAs using an all-in-one biosensor for breast cancer diagnosis

Analyst, 2020, 145,3289-3296
DOI: 10.1039/D0AN00393J, Paper
Huizhen Wang, Dinggeng He, Kejing Wan, Xiaowu Sheng, Hong Cheng, Jin Huang, Xiao Zhou, Xiaoxiao He, Kemin Wang
Herein, a simple all-in-one biosensor based on a DNA three-way junction has been constructed for in situ simultaneous detection of multiple miRNAs by competitive strand displacement.
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Recent developments of nanoenzyme-based colorimetric sensors for heavy metal detection and the interaction mechanism

Analyst, 2020, 145,3173-3187
DOI: 10.1039/D0AN00339E, Critical Review
Zhengquan Yan, Hua Yuan, Qi Zhao, Lin Xing, Xiaoyu Zheng, Weiguo Wang, Yulei Zhao, Yang Yu, Lei Hu, Wenli Yao
This work highlights the application and interaction mechanism of metal nanoparticles, metal oxides, metal sulfides, graphene-based nanomaterials and G-quadruplex, etc. in nanoenzyme-based colorimetric sensors.
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Paper-based platforms with coulometric readout for ascorbic acid determination in fruit juices

Analyst, 2020, 145,3431-3439
DOI: 10.1039/D0AN00477D, Paper
Estefanía Nunez-Bajo, M. Teresa Fernández-Abedul
Paper-based electrochemical platforms with coulometric readout are employed for fast and low cost determination of ascorbic acid in commercial juice samples.
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Model independent peak fitting and uncertainty assignment for high-precision time-of-flight mass spectrometry

Analyst, 2020, 145,3401-3406
DOI: 10.1039/D0AN00325E, Paper
Aleksey Vladimirovich Chudinov, Marco Rosenbusch, Vyacheslav Ivanovich Kozlovskiy, Valeriy Vladislavovich Raznikov, Peter Schury, Michiharu Wada, Hermann Wollnik
Logarithmic scale splines for smooth extraction of a native peak shape, and uncertainty estimation using direct trials.
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Time-resolved in situ monitoring of photocatalytic reactions by probe electrospray ionization mass spectrometry

Analyst, 2020, 145,3313-3319
DOI: 10.1039/D0AN00305K, Paper
Zhongbao Han, Xiaoyu Gu, Shirong Wang, Liyan Liu, Ying Wang, Zhen Zhao, Zhan Yu
We report the application of PESI-MS to in situ monitoring of photocatalytic reactions of cationic dyes in suspensions in real-time.
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Why ammonium detection is particularly challenging but insightful with ionophore-based potentiometric sensors – an overview of the progress in the last 20 years

Analyst, 2020, 145,3188-3210
DOI: 10.1039/D0AN00327A, Critical Review
Open Access
María Cuartero, Noemi Colozza, Bibiana M. Fernández-Pérez, Gastón A. Crespo
An overview of ionophore-based electrodes for ammonium sensing critically analyzing contributions in the last 20 years and with focus in analytical applications.
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An ionic-based carbon dot for enantioselective discrimination of nonaromatic amino alcohols

Analyst, 2020, 145,3395-3400
DOI: 10.1039/D0AN00399A, Paper
Datong Wu, Fei Pan, Li Gao, Yongxin Tao, Yong Kong
An ionic chiral carbon dot was designed and synthesized for the chiral recognition of nonaromatic amino alcohols.
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Highly sensitive and selective optosensing of quercetin based on novel complexation with yttrium ions

Analyst, 2020, 145,3376-3384
DOI: 10.1039/D0AN00117A, Paper
Nguyen Ngoc Nghia, Bui The Huy, Yong-Ill Lee
A simple and fast method was developed for the determination of quercetin using a Arduino-based portable device.
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Trace manganese detection via differential pulse cathodic stripping voltammetry using disposable electrodes: additively manufactured nanographite electrochemical sensing platforms

Analyst, 2020, 145,3424-3430
DOI: 10.1039/D0AN00018C, Paper
Open Access
Diego P. Rocha, Christopher W. Foster, Rodrigo A. A. Munoz, Gary A. Buller, Edmund M. Keefe, Craig E. Banks
Additive manufacturing is a promising technology for the rapid and economical fabrication of portable electroanalytical devices.
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Antibody free ELISA-like assay for the detection of transcription factors based on double-stranded DNA thermostability

Analyst, 2020, 145,3339-3344
DOI: 10.1039/C9AN02631B, Paper
Yue Sun, Zhiyan Li, Choiwan Lau, Jianzhong Lu
Transcription factors (TFs) play critical roles in gene expression regulation and disease development. Herein we report a chemiluminescence assay for the detection of transcription factor based on double-stranded DNA thermostability.
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An electrochemical sensor based on enzyme-free recycling amplification for sensitive and specific detection of miRNAs from cancer cells

Analyst, 2020, 145,3353-3358
DOI: 10.1039/D0AN00275E, Paper
Lili Jiang, Yuling Yang, Yuhong Lin, Ziyi Chen, Chao Xing, Chunhua Lu, Huanghao Yang, Shusheng Zhang
A catalyzed hairpin assembly and binding-induced formation of the DNA three-way junction for ultrasensitive electrochemical detection of diverse miRNAs is reported.
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An ultrasensitive electrochemiluminescence aptasensor for the detection of diethylstilbestrol based on the enhancing mechanism of the metal–organic framework NH2-MIL-125(Ti) in a 3,4,9,10-perylenetetracarboxylic acid/K2S2O8 system

Analyst, 2020, 145,3306-3312
DOI: 10.1039/D0AN00212G, Paper
Jingxian Li, Xueling Shan, Ding Jiang, Zhidong Chen
A novel electrochemiluminescence (ECL) aptasensor based on PTCA/NH2-MIL-125 for the determination of diethylstilbestrol.
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An SDS-PAGE based method for the quantification of carbon black in biological samples

Analyst, 2020, 145,3370-3375
DOI: 10.1039/D0AN00046A, Paper
Keyang Liu, Bin Wan
Quantification of Carbon Black (CB) in bio-samples was made available through SDS-PAGE gel electrophoresis.
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Electrochemiluminescence analysis of tryptophan in aqueous solutions based on its reaction with tetraphenylborate anions

Analyst, 2020, 145,3364-3369
DOI: 10.1039/D0AN00229A, Paper
Yuriy Zholudov, Natalia Lysak, Dmytro Snizhko, Olena Reshetniak, Guobao Xu
A pulsed electrogenerated chemiluminescence is observed upon the oxidation of tryptophan amino acid in aqueous solutions with a tetraphenylborate co-reactant.
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Analysis of deoxyribonuclease activity by conjugation-free fluorescence polarisation in sub-nanolitre droplets

Analyst, 2020, 145,3222-3228
DOI: 10.1039/C9AN02380A, Paper
Jae-Won Choi, Bala Murali Krishna Vasamsetti, Jaebum Choo, Hak Yong Kim
Deoxyribonuclease (DNase) assay using ethidium bromide (EtBr) molecules by conjugation-free fluorescence polarisation under visible light in a droplet-based microfluidic chip.
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A disposable molecularly imprinted electrochemical sensor for the ultra-trace detection of the organophosphorus insecticide phosalone employing monodisperse Pt-doped UiO-66 for signal amplification

Analyst, 2020, 145,3245-3256
DOI: 10.1039/D0AN00278J, Paper
Liping Xu, Jiebin Li, Jiajia Zhang, Junyong Sun, Tian Gan, Yanming Liu
A disposable electrochemical sensor was fabricated based on monodisperse Pt-doped UiO-66 and a mesoporous molecularly imprinted polymer to specifically detect phosalone.
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Fluorescence chemosensing of meldonium using a cross-reactive sensor array

Analyst, 2020, 145,3345-3352
DOI: 10.1039/D0AN00209G, Paper
Ergin Yalcin, Cem Erkmen, Tugba Taskin-Tok, Mehmet Gokhan Caglayan
Differential sensing of meldonium was achieved using fluorescent chemosensors.
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Label-free analytical performances of a peptide-based QCM biosensor for trypsin

Analyst, 2020, 145,3329-3338
DOI: 10.1039/D0AN00308E, Paper
Zong-Mu Dong, Lu Cheng, Ping Zhang, Guang-Chao Zhao
Peptide chains that can be specifically hydrolyzed by trypsin were synthesized and fabricated with Au NPs-MCA on a QCM electrode for the sensitive quantification of trypsin in a complex matrix.
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In vitro simultaneous mapping of the partial pressure of oxygen, pH and inorganic phosphate using electron paramagnetic resonance

Analyst, 2020, 145,3236-3244
DOI: 10.1039/D0AN00168F, Paper
Akihiro Taguchi, Stephen DeVience, Benoit Driesschaert, Valery V. Khramtsov, Hiroshi Hirata
A simultaneous mapping method was established for the partial pressure of oxygen, pH and inorganic phosphate using electron paramagnetic resonance.
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Rapid and accurate identification of marine microbes with single-cell Raman spectroscopy

Analyst, 2020, 145,3297-3305
DOI: 10.1039/C9AN02069A, Paper
Yaoyao Liu, Jingjing Xu, Yi Tao, Teng Fang, Wenbin Du, Anpei Ye
Rapid and accurate identification of individual microorganisms using single-cell Raman spectra combining with one-dimensional convolutional neural networks.
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Accelerated non-crosslinking assembly of DNA-functionalized nanoparticles in alcoholic solvents: for application in the identification of clear liquors

Analyst, 2020, 145,3229-3235
DOI: 10.1039/D0AN00029A, Paper
Luyang Wang, Guoqing Wang, Yali Shi, Lan Zhang, Ran An, Tohru Takarada, Mizuo Maeda, Xingguo Liang
Accelerated aggregation of DNA-functionalized gold nanoparticles is discovered in alcoholic solvents upon adding full-match DNA and is potentially useful for the identification of Baijiu.
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A traceless clean-up method coupled with gas chromatography and mass spectrometry for analyzing polycyclic aromatic hydrocarbons in complex plant leaf matrices

Analyst, 2020, 145,3266-3273
DOI: 10.1039/D0AN00128G, Paper
Xiangzi Jin, Han Yeong Kaw, Huijie Li, Zhao Wang, Jinhua Zhao, Xiangfan Piao, Donghao Li, Dongri Jin, Miao He
This study developed a traceless clean-up method by combining solid phase extraction (SPE) with gas purge–microsyringe extraction (GP–MSE) to purify sample extracts for the determination of polycyclic aromatic hydrocarbons (PAHs) in plant leaves.
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iso-μmGene: Isothermal amplification-based portable microfluidic system for simple, reliable and flexibly multiplexed Genetic identification and quantification

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00560F, Paper
Runtao Zhong, Shilin Liu, Guohao Zhang, Mengyu Wang, Yeqing Sun
Simple, reliable and flexibly multiplexed genetic identification and quantification of microbial pathogens is in urgent need for early disease diagnosis and timely treatment. This study presented an isothermal amplification-based portable...
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Changes in latent fingermark glyceride composition as a function of sample age using UPLC-IMS-QToF-MSE

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00379D, Paper
Amanda Frick, Natalie Kummer, Ana Moraleda, Celine Weyermann
The composition of fingermark residue has been an important topic in forensic science, mainly in efforts to better understand and eventually improve the efficacy of latent fingermark detection methods. While...
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A signal cascade amplification strategy based on RT-PCR triggering of G-quadruplex DNAzyme for a novel electrochemical detection of viable Cronobacter sakazakii

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00270D, Paper
Yuanyuan Yuan, Xianyong Wu, Zhanmin Liu, QIqi Ning, Liqiang Fu, Sujuan Wu
Cronobacter sakazakii is an important opportunistic food-borne pathogen, and it can cause severe diseases with main symptoms including neonatal meningitis, necrotizing enterocolitis, and sepsis. For the achievement of practical and...
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A polypyrrole-coated eightfold-helical Wells–Dawson POM-based Cu-FKZ framework for enhanced colorimetric sensing

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00402B, Paper
Qian Li, Mingqi Xu, Xiao Li, Shuxian Li, Liran Hou, Yuhao Chen, Jingquan Sha
A new Wells–Dawson-type CuFKZP2W18-based hybrid compound containing eightfold helical chains is reported, and its CuFKZP2W18/PPy(15%) composite exhibits excellent peroxidase-like catalytic activity.
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Portable surface-enhanced Raman scattering analysis performed with microelectrode-templated silver nanodendrites

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00484G, Paper
Joshua Raveendran, Aristides Docoslis
Using a handheld Raman spectrometer, we demonstrate how silver nanodendritic substrates formed on microelectrode platforms can be used for ultrasensitive detection of target analytes, such as cocaine and melamine. The...
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Correction: Gold alloy-based nanozyme sensor arrays for biothiol detection

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN90044C, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Junshu Lin, Quan Wang, Xiaoyu Wang, Yunyao Zhu, Xi Zhou, Hui Wei
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Analytical science in neurochemistry

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN90043E, Editorial
Jean-Francois Masson, Parastoo Hashemi, Martyn G. Boutelle
Jean-François Masson, Parastoo Hashemi and Martyn Boutelle introduce the Analyst themed collection on Analytical Science in Neurochemistry.
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A portable electrochemiluminescence bipolar electrode array for the visualized sensing of Cas9 activity

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00678E, Paper
Rui Guo, Shanwen Hu, Zonghua Wang
A new type of closed BPE-ECL system based on an Au electric circuit at a portable substrate is designed for the visualized sensing of Cas9 Activity in the CRISPR/Cas9 system.
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Enzyme-activated anchoring of peptide probes onto plasma membranes for selectively lighting up target cells

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00487A, Paper
Julan Xia, Sujuan Sun, Xianhua Wu, Yan Huang, Chunyang Lei, Zhou Nie
Enzyme-activated membrane insertion peptide probes were developed for selectively lighting up target cells.
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Ferguson analysis of protein electromigration during single-cell electrophoresis in an open microfluidic device

Analyst, 2020, Advance Article
DOI: 10.1039/C9AN02553G, Paper
Kristine Y. Tan, Amy E. Herr
Ferguson analysis of protein electromigration from single-cell lysate in an open microfluidic device to inform optimal assay design.
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Kinetic study of azobenzene E/Z isomerization using ion mobility-mass spectrometry and liquid chromatography-UV detection

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00048E, Paper
Salomé Poyer, Chang Min Choi, Claire Deo, Nicolas Bogliotti, Juan Xie, Philippe Dugourd, Fabien Chirot, Jean-Yves Salpin
Liquid chromatography with UV detection and ion mobility-mass spectrometry are evaluated to study the EZ thermal back relaxation kinetics of azobenzenes.
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Simultaneous detection of plant growth regulators jasmonic acid and methyl jasmonate in plant samples by a monoclonal antibody-based ELISA

Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00203H, Paper
Minghui Yi, Linchuan Zhao, Kang Wu, Chang Liu, Diandian Deng, Kang Zhao, Jianguo Li, Anping Deng
Methyl jasmonate (MeJA) and its free-acid form, jasmonic acid (JA), collectively referred to as jasmonates (JAs), are natural plant growth regulators that are widely present in higher plants.
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DNA binding fluorescent proteins as single-molecule probes

Analyst, 2020, Accepted Manuscript
DOI: 10.1039/D0AN00218F, Critical Review
Kyubong Jo, Xuelin Jin, Natalia Diyah Hapsari, Seunghyun Lee
DNA binding fluorescent proteins are useful probes for a broad range of biological applications. Fluorescent protein (FP)-tagging allows DNA binding proteins expressed within a living cell to be directly visualized,...
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