The protective effect of thymoquinone on tert-butylhydroquinone induced cytotoxicity in human umbilical vein endothelial cells
Toxicol. Res., 2019, 8,1050-1056
DOI: 10.1039/C9TX00235A, Paper
DOI: 10.1039/C9TX00235A, Paper
Zahra Karimi, Maryam Ghaffari, Jafar Ezzati Nazhad Dolatabadi, Parvin Dehghan
2-tert-Butyl-4-hydroquinone (TBHQ) is used for inhibition of oxidative rancidity in the food industry.
The content of this RSS Feed (c) The Royal Society of Chemistry
2-tert-Butyl-4-hydroquinone (TBHQ) is used for inhibition of oxidative rancidity in the food industry.
The content of this RSS Feed (c) The Royal Society of Chemistry
Cytotoxic effect of silica nanoparticles against hepatocellular carcinoma cells through necroptosis induction
Toxicol. Res., 2019, 8,1042-1049
DOI: 10.1039/C9TX00240E, Paper
DOI: 10.1039/C9TX00240E, Paper
Yuexiang Niu, Engong Tang, Qingan Zhang
Hepatocellular carcinoma (HCC) is a common cancer that affects people worldwide with high morbidity and mortality, and its resistance to current chemotherapeutic drugs is a serious concern.
The content of this RSS Feed (c) The Royal Society of Chemistry
Hepatocellular carcinoma (HCC) is a common cancer that affects people worldwide with high morbidity and mortality, and its resistance to current chemotherapeutic drugs is a serious concern.
The content of this RSS Feed (c) The Royal Society of Chemistry
Benzoquinone alters the lipid homeostasis in Saccharomyces cerevisiae
Toxicol. Res., 2019, 8,1035-1041
DOI: 10.1039/C9TX00139E, Paper
DOI: 10.1039/C9TX00139E, Paper
Abhishek Raj, Vasanthi Nachiappan
BQ exposure inhibited cell growth, increased the ROS-mediated apoptosis, and altered the phospholipids that resulted in membrane proliferation.
The content of this RSS Feed (c) The Royal Society of Chemistry
BQ exposure inhibited cell growth, increased the ROS-mediated apoptosis, and altered the phospholipids that resulted in membrane proliferation.
The content of this RSS Feed (c) The Royal Society of Chemistry
Phytochemicals protect L02 cells against hepatotoxicity induced by emodin via the Nrf2 signaling pathway
Toxicol. Res., 2019, 8,1028-1034
DOI: 10.1039/C9TX00220K, Paper
DOI: 10.1039/C9TX00220K, Paper
Yan Yan, Kang Wang, Xu Tang, Jun-feng Gao, Bin-yu Wen
Dihydromyricetin (DMY), hyperoside and silybin are phytochemicals that belong to a class called flavonoids, and they have been used in liver protection pharmaceutical preparations, but the specific mechanism of these chemicals is still unclarified.
The content of this RSS Feed (c) The Royal Society of Chemistry
Dihydromyricetin (DMY), hyperoside and silybin are phytochemicals that belong to a class called flavonoids, and they have been used in liver protection pharmaceutical preparations, but the specific mechanism of these chemicals is still unclarified.
The content of this RSS Feed (c) The Royal Society of Chemistry
Application of the direct peptide reactivity assay (DPRA) to inorganic compounds: a case study of platinum species
Toxicol. Res., 2019, 8,802-814
DOI: 10.1039/C9TX00242A, Paper
DOI: 10.1039/C9TX00242A, Paper
Jocelyn D. C. Hemming, Mark Hosford, Martin M. Shafer
The in chemico Direct Peptide Reactivity Assay (DPRA) was developed as a non-animal, relatively high throughput, screening tool for skin sensitization potential.
The content of this RSS Feed (c) The Royal Society of Chemistry
The in chemico Direct Peptide Reactivity Assay (DPRA) was developed as a non-animal, relatively high throughput, screening tool for skin sensitization potential.
The content of this RSS Feed (c) The Royal Society of Chemistry
Nanoparticle induced barrier function assessment at liquid–liquid and air–liquid interface in novel human lung epithelia cell lines
Toxicol. Res., 2019, 8,1016-1027
DOI: 10.1039/C9TX00179D, Paper
DOI: 10.1039/C9TX00179D, Paper
Open Access
This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Lars Leibrock, Sandra Wagener, Ajay Vikram Singh, Peter Laux, Andreas Luch
To answer questions about nanoparticle toxicity, translocation and biokinetics following inhalation exposure, in vitro models should have functional barrier properties to mimic the in vivo situation as closely as possible.
The content of this RSS Feed (c) The Royal Society of Chemistry
To answer questions about nanoparticle toxicity, translocation and biokinetics following inhalation exposure, in vitro models should have functional barrier properties to mimic the in vivo situation as closely as possible.
The content of this RSS Feed (c) The Royal Society of Chemistry
Astaxanthin reduces perfluorooctanoic acid cytotoxicity in Saccharomyces cerevisiae
Toxicol. Res., 2019, 8,1009-1015
DOI: 10.1039/C9TX00215D, Paper
DOI: 10.1039/C9TX00215D, Paper
S. J. Sudharshan, Raghavendra Tirupathi, Madhu Dyavaiah
Perfluorooctanoic acid (PFA) has been identified as an environmental contaminant of high concern for human health.
The content of this RSS Feed (c) The Royal Society of Chemistry
Perfluorooctanoic acid (PFA) has been identified as an environmental contaminant of high concern for human health.
The content of this RSS Feed (c) The Royal Society of Chemistry
Astilbin attenuates cerebral ischemia/reperfusion injury by inhibiting the TLR4/MyD88/NF-κB pathway
Toxicol. Res., 2019, 8,1002-1008
DOI: 10.1039/C9TX00222G, Paper
DOI: 10.1039/C9TX00222G, Paper
Jing Li, Zhaowei Gu, Yue Liu, Yu Wang, Min Zhao
Ischemic stroke is the second most common cause of death worldwide and cerebral ischemia/reperfusion (I/R) injury also leads to serious tissue damage.
The content of this RSS Feed (c) The Royal Society of Chemistry
Ischemic stroke is the second most common cause of death worldwide and cerebral ischemia/reperfusion (I/R) injury also leads to serious tissue damage.
The content of this RSS Feed (c) The Royal Society of Chemistry
Methanol extract of Iphiona aucheri ameliorates CCl4 induced hepatic injuries by regulation of genes in rats
Toxicol. Res., 2019, 8,815-832
DOI: 10.1039/C9TX00157C, Paper
DOI: 10.1039/C9TX00157C, Paper
Jawaid Ahmed Zai, Muhammad Rashid Khan, Zaib un Nisa Mughal, Riffat Batool, Irum Naz, Sonia Maryam, Zartash Zahra
Alteration in expression of ER stress associated genes, inflammatory genes and antioxidant biochemical induced with CCl4 in liver of rats were restored towards the control rats by co-administration of methanol extract of Iphiona aucheri to rats.
The content of this RSS Feed (c) The Royal Society of Chemistry
Alteration in expression of ER stress associated genes, inflammatory genes and antioxidant biochemical induced with CCl4 in liver of rats were restored towards the control rats by co-administration of methanol extract of Iphiona aucheri to rats.
The content of this RSS Feed (c) The Royal Society of Chemistry
Effects of moderate red wine on cardiovascular risk factors in diabetics: a systematic review and meta-analysis of randomized controlled trials
Toxicol. Res., 2019, 8,979-987
DOI: 10.1039/C9TX00227H, Paper
DOI: 10.1039/C9TX00227H, Paper
Saavia Alice Naame, Decheng Li, Ruixue Huang
Diabetes mellitus is of major public health concerns; its incidence is continuously increasing.
The content of this RSS Feed (c) The Royal Society of Chemistry
Diabetes mellitus is of major public health concerns; its incidence is continuously increasing.
The content of this RSS Feed (c) The Royal Society of Chemistry
Mice with a Sertoli cell-specific knockout of the Ctr1 gene exhibit a reduced sensitivity to cisplatin-induced testicular germ cell apoptosis
Toxicol. Res., 2019, 8,972-978
DOI: 10.1039/C9TX00142E, Paper
DOI: 10.1039/C9TX00142E, Paper
Open Access
This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Rashin Ghaffari, John H. Richburg
Exposure to the chemotherapeutic agent cis-diamminedichloroplatinum(II) (cDDP) is well known to instigate acute and prolonged testicular injury in male patients.
The content of this RSS Feed (c) The Royal Society of Chemistry
Exposure to the chemotherapeutic agent cis-diamminedichloroplatinum(II) (cDDP) is well known to instigate acute and prolonged testicular injury in male patients.
The content of this RSS Feed (c) The Royal Society of Chemistry
Cigarette smoke inhalation aggravates diabetic kidney injury in rats
Toxicol. Res., 2019, 8,964-971
DOI: 10.1039/C9TX00201D, Paper
DOI: 10.1039/C9TX00201D, Paper
Songling Jiang, Do Van Quan, Jae Hyuck Sung, Moo-Yeol Lee, Hunjoo Ha
Four weeks of exposure to cigarette smoke aggravated the progression of diabetic kidney injury including inflammation, fibrosis, and oxidative stress.
The content of this RSS Feed (c) The Royal Society of Chemistry
Four weeks of exposure to cigarette smoke aggravated the progression of diabetic kidney injury including inflammation, fibrosis, and oxidative stress.
The content of this RSS Feed (c) The Royal Society of Chemistry
Novel evaluation of sevoflurane anesthetic exposure on the testicular germ cells of neonatal male mice
Toxicol. Res., 2019, 8,988-993
DOI: 10.1039/C9TX00193J, Paper
DOI: 10.1039/C9TX00193J, Paper
Ali Raza Ebrahim Soltani, Abdolmohammad Kajbafzadeh, Maryam Ezzati, Zahra Ebrahim Soltani, Navid Hosseinifar, Anahid Maleki, Maryam Nezhad Sistani
Inhalatory anesthetics may impact spermatogenesis and sexual behavior.
The content of this RSS Feed (c) The Royal Society of Chemistry
Inhalatory anesthetics may impact spermatogenesis and sexual behavior.
The content of this RSS Feed (c) The Royal Society of Chemistry
Innovative models for in vitro detection of seizure
Toxicol. Res., 2019, 8,784-788
DOI: 10.1039/C9TX00210C, Review Article
DOI: 10.1039/C9TX00210C, Review Article
Kimberly L. Rockley, Ruth A. Roberts, Michael J. Morton
New technologies offer the opportunity to screen for seizure liability in vitro, avoiding costly failures in preclinical and clinical development.
The content of this RSS Feed (c) The Royal Society of Chemistry
New technologies offer the opportunity to screen for seizure liability in vitro, avoiding costly failures in preclinical and clinical development.
The content of this RSS Feed (c) The Royal Society of Chemistry
Synergistic antioxidant capacity of CsNPs and CurNPs against cytotoxicity, genotoxicity and pro-inflammatory mediators induced by hydroxyapatite nanoparticles in male rats
Toxicol. Res., 2019, 8,939-952
DOI: 10.1039/C9TX00221A, Paper
DOI: 10.1039/C9TX00221A, Paper
Israa F. Mosa, Mokhtar Youssef, Maher Kamel, Osama F. Mosa, Yasser Helmy
Due to their dynamic characteristics, hydroxyapatite nanoparticles (HAP-NPs) have been employed numerous times in nanomedicine and in tissue engineering, particularly as diagnostic and therapeutic agents.
The content of this RSS Feed (c) The Royal Society of Chemistry
Due to their dynamic characteristics, hydroxyapatite nanoparticles (HAP-NPs) have been employed numerous times in nanomedicine and in tissue engineering, particularly as diagnostic and therapeutic agents.
The content of this RSS Feed (c) The Royal Society of Chemistry
Cadmium telluride quantum dot-exposed human bronchial epithelial cells: a further study of the cellular response by proteomics
Toxicol. Res., 2019, 8,994-1001
DOI: 10.1039/C9TX00126C, Paper
DOI: 10.1039/C9TX00126C, Paper
Yan-Ming Xu, Heng Wee Tan, Wei Zheng, Zhan-Ling Liang, Fei-Yuan Yu, Dan-Dan Wu, Yue Yao, Qiu-Hua Zhong, Rui Yan, Andy T. Y. Lau
A comparative proteome analysis was conducted to identify global changes in the protein expression profiles of cadmium telluride quantum dot-exposed human bronchial epithelial BEAS-2B cells.
The content of this RSS Feed (c) The Royal Society of Chemistry
A comparative proteome analysis was conducted to identify global changes in the protein expression profiles of cadmium telluride quantum dot-exposed human bronchial epithelial BEAS-2B cells.
The content of this RSS Feed (c) The Royal Society of Chemistry
Biogenic Aspergillus tubingensis silver nanoparticles’ in vitro effects on human umbilical vein endothelial cells, normal human fibroblasts, HEPG2, and Galleria mellonella
Toxicol. Res., 2019, 8,789-801
DOI: 10.1039/C9TX00091G, Paper
DOI: 10.1039/C9TX00091G, Paper
Cristiane Angélica Ottoni, Durvanei Augusto Maria, Priscila Jane Romano de Oliveira Gonçalves, Welington Luiz de Araújo, Ana Olívia de Souza
Biogenic silver nanoparticles are ecofriendly and offers valuable possibilities of applications in several industrial areas.
The content of this RSS Feed (c) The Royal Society of Chemistry
Biogenic silver nanoparticles are ecofriendly and offers valuable possibilities of applications in several industrial areas.
The content of this RSS Feed (c) The Royal Society of Chemistry
Reply to the ‘Comment on “Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use”’ by M. E. Mullins, M. C. Yarema, M. L. A. Sivilotti, M. Thompson, D. A. Algren, M. C. Beuhler and C. P. Holstege, Toxicol. Res., 2019, 8, DOI: 10.1039/C9T
Toxicol. Res., 2019, 8,1059-1059
DOI: 10.1039/C9TX00216B, Comment
DOI: 10.1039/C9TX00216B, Comment
Open Access
This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
D. Nicholas Bateman, James W. Dear
Mullins et al. made a comment on our article (DOI: 10.1039/C9TX00002J) stating they noticed the omission of the one-bag, standard concentration protocol which is shared by several centers in North America when we discussed IV acetylcysteine protocols.
The content of this RSS Feed (c) The Royal Society of Chemistry
Mullins et al. made a comment on our article (DOI: 10.1039/C9TX00002J) stating they noticed the omission of the one-bag, standard concentration protocol which is shared by several centers in North America when we discussed IV acetylcysteine protocols.
The content of this RSS Feed (c) The Royal Society of Chemistry
Environmental distribution of the neurotoxin L-BMAA in Paenibacillus species
Toxicol. Res., 2019, 8,781-783
DOI: 10.1039/C9TX00203K, Viewpoint
DOI: 10.1039/C9TX00203K, Viewpoint
Peter B. Nunn, Geoffrey A. Codd
The neurotoxic amino acid, 3-N-methyl-2,3-diaminopropanoic acid (BMAA), known in plants of the genus Cycas and in aquatic cyanobacteria and other organisms, is a component of antibiotic peptides in two species of Paenibacillus.
The content of this RSS Feed (c) The Royal Society of Chemistry
The neurotoxic amino acid, 3-N-methyl-2,3-diaminopropanoic acid (BMAA), known in plants of the genus Cycas and in aquatic cyanobacteria and other organisms, is a component of antibiotic peptides in two species of Paenibacillus.
The content of this RSS Feed (c) The Royal Society of Chemistry
Thyroid endocrine status and biochemical stress responses in adult male Wistar rats chronically exposed to pristine polystyrene nanoplastics
Toxicol. Res., 2019, 8,953-963
DOI: 10.1039/C9TX00147F, Paper
DOI: 10.1039/C9TX00147F, Paper
Fatemeh Amereh, Akbar Eslami, Simin Fazelipour, Mohammad Rafiee, Mohammad Ismail Zibaii, Mohammad Babaei
At this time, little is known about the long-term effects of micro(nano)plastics on public health. In the present study, early warning signs of thyroid endocrine disruption were noticed in adult Wistar rats from the ingestion of virgin polystyrene nanoparticles.
The content of this RSS Feed (c) The Royal Society of Chemistry
At this time, little is known about the long-term effects of micro(nano)plastics on public health. In the present study, early warning signs of thyroid endocrine disruption were noticed in adult Wistar rats from the ingestion of virgin polystyrene nanoparticles.
The content of this RSS Feed (c) The Royal Society of Chemistry
Lipoic acid antagonizes paraquat-induced vascular endothelial dysfunction by suppressing mitochondrial reactive oxidative stress
Toxicol. Res., 2019, 8,918-927
DOI: 10.1039/C9TX00186G, Paper
DOI: 10.1039/C9TX00186G, Paper
Li Pang, Ping Deng, Yi-dan Liang, Jing-yu Qian, Li-Chuan Wu, Ling-ling Yang, Zheng-ping Yu, Zhou Zhou
α-Lipoic acid antagonizes paraquat toxicity.
The content of this RSS Feed (c) The Royal Society of Chemistry
α-Lipoic acid antagonizes paraquat toxicity.
The content of this RSS Feed (c) The Royal Society of Chemistry
Gynura divaricata ameliorates hepatic insulin resistance by modulating insulin signalling, maintaining glycolipid homeostasis and reducing inflammation in type 2 diabetic mice
Toxicol. Res., 2019, 8,928-938
DOI: 10.1039/C9TX00191C, Paper
DOI: 10.1039/C9TX00191C, Paper
Xuan Dong, Shu-Xiang Zhao, Bing-Qing Xu, Yu-Qing Zhang
Oral lyophilized powder of Gynura divaricata, an edible medicinal plant, can alleviate both hyperglycaemia and hepatic insulin resistance in type 2 diabetic mice.
The content of this RSS Feed (c) The Royal Society of Chemistry
Oral lyophilized powder of Gynura divaricata, an edible medicinal plant, can alleviate both hyperglycaemia and hepatic insulin resistance in type 2 diabetic mice.
The content of this RSS Feed (c) The Royal Society of Chemistry
Ex vivo toxicological evaluation of experimental anticancer gold(I) complexes with lansoprazole-type ligands
Toxicol. Res., 2019, 8,885-895
DOI: 10.1039/C9TX00149B, Paper
DOI: 10.1039/C9TX00149B, Paper
Natalia Estrada-Ortiz, Elena Lopez-Gonzales, Ben Woods, Stefan Stürup, Inge A. M. de Graaf, Geny M. M. Groothuis, Angela Casini
Novel experimental anticancer gold-based compounds were studied for their mechanisms of toxicity in healthy rat kidney and liver tissues, using the Precision Cut Tissue Slices (PCTS) technique.
The content of this RSS Feed (c) The Royal Society of Chemistry
Novel experimental anticancer gold-based compounds were studied for their mechanisms of toxicity in healthy rat kidney and liver tissues, using the Precision Cut Tissue Slices (PCTS) technique.
The content of this RSS Feed (c) The Royal Society of Chemistry
Characteristic synergistic cytotoxic effects toward cells in graphene oxide dressing with cadmium and copper ions
Toxicol. Res., 2019, 8,908-917
DOI: 10.1039/C9TX00146H, Paper
DOI: 10.1039/C9TX00146H, Paper
Yiyang Dong, Yulin Chang, Haidi Gao, Victoria Arantza León Anchustegui, Qiang Yu, Haifang Wang, Jia-Hui Liu, Shihui Wang
Cadmium ions exerted synergistic toxic effects with graphene oxide on Hela cells.
The content of this RSS Feed (c) The Royal Society of Chemistry
Cadmium ions exerted synergistic toxic effects with graphene oxide on Hela cells.
The content of this RSS Feed (c) The Royal Society of Chemistry
Comment on “Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use” by D. N. Bateman and J. W. Dear, Toxicol. Res., 2019, 8, 489
Toxicol. Res., 2019, 8,1057-1058
DOI: 10.1039/C9TX00158A, Comment
DOI: 10.1039/C9TX00158A, Comment
Michael E. Mullins, Mark C. Yarema, Marco L. A. Sivilotti, Margaret Thompson, D. Adam Algren, Michael C. Beuhler, Christopher P. Holstege
We point out an acetylcysteine protocol that a previous article (D. N. Bateman and J. W. Dear, Toxicol. Res., 2019, 8, 489–498) overlooked.
The content of this RSS Feed (c) The Royal Society of Chemistry
We point out an acetylcysteine protocol that a previous article (D. N. Bateman and J. W. Dear, Toxicol. Res., 2019, 8, 489–498) overlooked.
The content of this RSS Feed (c) The Royal Society of Chemistry
Kaempferol derivatives isolated from Lens culinaris Medik. reduce DNA damage induced by etoposide in peripheral blood mononuclear cells
Toxicol. Res., 2019, 8,896-907
DOI: 10.1039/C9TX00176J, Paper
DOI: 10.1039/C9TX00176J, Paper
Magdalena Kluska, Michał Juszczak, Daniel Wysokiński, Jerzy Żuchowski, Anna Stochmal, Katarzyna Woźniak
Bioactive compounds isolated from plants are considered to be attractive candidates for cancer therapy.
The content of this RSS Feed (c) The Royal Society of Chemistry
Bioactive compounds isolated from plants are considered to be attractive candidates for cancer therapy.
The content of this RSS Feed (c) The Royal Society of Chemistry
miR-140-5p mediates bevacizumab-induced cytotoxicity to cardiomyocytes by targeting the VEGFA/14-3-3γ signal pathway
Toxicol. Res., 2019, 8,875-884
DOI: 10.1039/C9TX00100J, Paper
DOI: 10.1039/C9TX00100J, Paper
Xuan-Ying Chen, Wei-Lin Huang, Xiao-Ping Peng, Yan-Ni Lv, Jun-He Li, Jian-Ping Xiong
Bevacizumab (BVZ) is a widely investigated angiogenesis inhibitor in cancer patients. Although the anti-tumor effects has been verified, cardiotoxicity may be the most serious side-effect for BVZ.
The content of this RSS Feed (c) The Royal Society of Chemistry
Bevacizumab (BVZ) is a widely investigated angiogenesis inhibitor in cancer patients. Although the anti-tumor effects has been verified, cardiotoxicity may be the most serious side-effect for BVZ.
The content of this RSS Feed (c) The Royal Society of Chemistry
Tin thiocarbonohydrazone complexes: synthesis, crystal structures and biological evaluation
Toxicol. Res., 2019, 8,862-867
DOI: 10.1039/C9TX00109C, Paper
DOI: 10.1039/C9TX00109C, Paper
Jin Wang, Yu-Ting Wang, Yan Fang, Yan-Li Lu, Ming-Xue Li
Three organotin thiocarbonohydrazone complexes have been synthesized, and growth inhibition assays indicated that complex 3 has the highest tumor cell selectivity.
The content of this RSS Feed (c) The Royal Society of Chemistry
Three organotin thiocarbonohydrazone complexes have been synthesized, and growth inhibition assays indicated that complex 3 has the highest tumor cell selectivity.
The content of this RSS Feed (c) The Royal Society of Chemistry
Eco-friendly synthesis of glutathione-capped CdTe/CdSe/ZnSe core/double shell quantum dots: their cytotoxicity and genotoxicity effects on Chinese hamster ovary cells
Toxicol. Res., 2019, 8,868-874
DOI: 10.1039/C9TX00113A, Paper
DOI: 10.1039/C9TX00113A, Paper
Neo Mervyn Monaheng, Sundararajan Parani, Mary Gulumian, Oluwatobi Samuel Oluwafemi
In this work, we report green one-pot synthesis, cytotoxicity and genotoxicity of glutathione-capped CdTe/CdSe/ZnSe heterostructured quantum dots (QDs) using a label-free xCELLigence RTCA system as well as the Cytokinesis Blocked Micronucleus assay.
The content of this RSS Feed (c) The Royal Society of Chemistry
In this work, we report green one-pot synthesis, cytotoxicity and genotoxicity of glutathione-capped CdTe/CdSe/ZnSe heterostructured quantum dots (QDs) using a label-free xCELLigence RTCA system as well as the Cytokinesis Blocked Micronucleus assay.
The content of this RSS Feed (c) The Royal Society of Chemistry
Integrated network pharmacology and targeted metabolomics to reveal the mechanism of nephrotoxicity of triptolide
Toxicol. Res., 2019, 8,850-861
DOI: 10.1039/C9TX00067D, Paper
DOI: 10.1039/C9TX00067D, Paper
Wei Huang, Chuanxin Liu, Lijuan Xie, Yuming Wang, Yanyan Xu, Yubo Li
Integrated network pharmacology and targeted metabolomics to reveal the nephrotoxicity mechanism of triptolide.
The content of this RSS Feed (c) The Royal Society of Chemistry
Integrated network pharmacology and targeted metabolomics to reveal the nephrotoxicity mechanism of triptolide.
The content of this RSS Feed (c) The Royal Society of Chemistry
Prometryn induces apoptotic cell death through cell cycle arrest and oxidative DNA damage
Toxicol. Res., 2019, 8,833-841
DOI: 10.1039/C9TX00080A, Paper
DOI: 10.1039/C9TX00080A, Paper
Qiaoyun Liu, Longsheng Wang, Hanwen Chen, Bo Huang, Jiawei Xu, Ying Li, Paul Héroux, Xinqiang Zhu, Yihua Wu, Dajing Xia
Prometryn induces oxidative stress-mediated DNA damage; Prometryn induces S phase of cell cycle arrest; Prometryn induces Bax-dependent apoptosis in BEAS-2B cells.
The content of this RSS Feed (c) The Royal Society of Chemistry
Prometryn induces oxidative stress-mediated DNA damage; Prometryn induces S phase of cell cycle arrest; Prometryn induces Bax-dependent apoptosis in BEAS-2B cells.
The content of this RSS Feed (c) The Royal Society of Chemistry
Serum miRNAs are differentially altered by ethanol and caffeine consumption in rats
Toxicol. Res., 2019, 8,842-849
DOI: 10.1039/C9TX00069K, Paper
DOI: 10.1039/C9TX00069K, Paper
M. Martinez, I. M. U. Rossetto, R. M. S. Arantes, F. S. N. Lizarte, L. F. Tirapelli, D. P. C. Tirapelli, L. G. A. Chuffa, F. E. Martinez
Alcoholism is a multifactorial disease with high risk for dependence determined by genetic background, environmental factors and neuroadaptations.
The content of this RSS Feed (c) The Royal Society of Chemistry
Alcoholism is a multifactorial disease with high risk for dependence determined by genetic background, environmental factors and neuroadaptations.
The content of this RSS Feed (c) The Royal Society of Chemistry
Effective intracellular delivery of bevacizumab via PEGylated polymeric nanoparticles targeting CD44v6 receptor in colon cancer cells
Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00556H, Paper
DOI: 10.1039/D0BM00556H, Paper
Ana Baião, Flávia Sousa, Ana Oliveira, Carla Oliveira, Bruno Sarmento
Colorectal cancer (CRC) is one of the most incident and mortal cancers in the world, mainly due to its metastatic and metabolic ability. CD44 receptor isoform containing exon 6 (CD44v6)...
The content of this RSS Feed (c) The Royal Society of Chemistry
Colorectal cancer (CRC) is one of the most incident and mortal cancers in the world, mainly due to its metastatic and metabolic ability. CD44 receptor isoform containing exon 6 (CD44v6)...
The content of this RSS Feed (c) The Royal Society of Chemistry
Functionalized Biomaterials to Combat Biofilm
Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00526F, Minireview
DOI: 10.1039/D0BM00526F, Minireview
Dan-ni Huang, Jing Wang, Kefeng Ren, Jian Ji
Pathogenic microbial biofilms readily form on implantable medical devices or human tissues have posed a great threat to worldwide healthcare. Hopes are focused on preventive strategies of biofilms, leaving a...
The content of this RSS Feed (c) The Royal Society of Chemistry
Pathogenic microbial biofilms readily form on implantable medical devices or human tissues have posed a great threat to worldwide healthcare. Hopes are focused on preventive strategies of biofilms, leaving a...
The content of this RSS Feed (c) The Royal Society of Chemistry
A biomimetic orally targeted delivery of Bindarit for immunotherapy of atherosclerosis
Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00418A, Paper
DOI: 10.1039/D0BM00418A, Paper
Luqi Yin, Cuiping Peng, Yue Tang, Yuchuan Yuan, Jiaxing Liu, Tingting Xiang, Feila Liu, Zhou Xing, Xiaohui Li
Monocyte chemoattractant protein-1 (MCP-1) plays an important role in the development of atherosclerosis. However, the application of bindarit (a specific synthetic inhibitor of MCP-1) in atherosclerosis has not been confirmed...
The content of this RSS Feed (c) The Royal Society of Chemistry
Monocyte chemoattractant protein-1 (MCP-1) plays an important role in the development of atherosclerosis. However, the application of bindarit (a specific synthetic inhibitor of MCP-1) in atherosclerosis has not been confirmed...
The content of this RSS Feed (c) The Royal Society of Chemistry
Surface engineering of titanium alloy using metal-polyphenol network coating with magnesium ions for improved osseointegration
Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00566E, Paper
DOI: 10.1039/D0BM00566E, Paper
Sangmin Lee, Yun-Young Chang, Jinkyu Lee, Sajeesh Kumar Madhurakkat Perikamana, Eun Mi Kim, Yang-Hun Jung, Jeong-Ho Yun, Heungsoo Shin
Although titanium-based implants are widely used in orthopedic and dental clinics, improved osseointegration at the bone–implant interface is still required.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Although titanium-based implants are widely used in orthopedic and dental clinics, improved osseointegration at the bone–implant interface is still required.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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A transport system based on a quantum dot-modified nanotracer is genetically and developmentally stable in pregnant mice
Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00311E, Paper
DOI: 10.1039/D0BM00311E, Paper
Open Access
This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Hye Jin Kim, Ji Sun Park, Se Won Yi, Minyeon Go, Hye-Ryun Kim, Su Jin Lee, Jong Min Park, Dong Hyun Cha, Sung Han Shim, Keun-Hong Park
The use of nanoscale materials (NMs) could cause problems such as cytotoxicity, genomic aberration, but the impacts of NM exposure during pregnancy remain uncharacterized in the context of clinical applications.
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The use of nanoscale materials (NMs) could cause problems such as cytotoxicity, genomic aberration, but the impacts of NM exposure during pregnancy remain uncharacterized in the context of clinical applications.
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Optically controlled hybrid metamaterial of plasmonic spiky gold inbuilt graphene sheets for bimodal imaging guided multimodal therapy
Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00312C, Paper
DOI: 10.1039/D0BM00312C, Paper
Kunnumpurathu Jibin, Jayaram S. Prasad, Giridharan Saranya, Sachin J. Shenoy, Kaustabh K. Maiti, Ramapurath S. Jayasree
Gold–graphene nanohybrid for simultaneous dual-imaging guided triple therapy as a new paradigm in light-triggered cancer theranostics. The material demonstrates excellent therapeutic efficacy and treatment monitoring features.
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Gold–graphene nanohybrid for simultaneous dual-imaging guided triple therapy as a new paradigm in light-triggered cancer theranostics. The material demonstrates excellent therapeutic efficacy and treatment monitoring features.
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Coupling PEG-LZM Polymer Network with Polyphenol Yields Suturable Biohydrogel for Tissue Patching
Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00429D, Paper
DOI: 10.1039/D0BM00429D, Paper
Haoqi Tan, Junjie Sun, Dawei Jin, Jialin Song, Miao Lei, Artem Antoshin, Xin Chen, Meng Yin, Xue Qu, Changsheng Liu
Poor mechanical performances severely limit the application of hydrogel in vivo, for example, it is difficult to perform a very common suturing operation on hydrogel during surgery. There is a...
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Poor mechanical performances severely limit the application of hydrogel in vivo, for example, it is difficult to perform a very common suturing operation on hydrogel during surgery. There is a...
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A versatile ultrafine and super-absorptive H+-modified montmorillonite: application for metabolic syndrome intervention and gastric mucosal protection
Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00474J, Paper
DOI: 10.1039/D0BM00474J, Paper
Qiwen Wang, Jie Shen, Enqi Mo, Haotian Zhang, Jianwei Wang, Xiurong Hu, Jun Zhou, Hongzhen Bai, Guping Tang
An H+-modified montmorillonite (H-MMT) was prepared using an acid modification method to obtain powerful absorption ability as a theranostic platform for both metabolic syndrome and gastric mucosa protection.
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An H+-modified montmorillonite (H-MMT) was prepared using an acid modification method to obtain powerful absorption ability as a theranostic platform for both metabolic syndrome and gastric mucosa protection.
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A super-stretchable, self-healing and injectable supramolecular hydrogel constructed by a host–guest crosslinker
Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00290A, Paper
DOI: 10.1039/D0BM00290A, Paper
Yang Zhou, Yuanhao Zhang, Zhaobo Dai, Fang Jiang, Jia Tian, Weian Zhang
Supramolecular hydrogels based on host–guest interactions have drawn considerable attention due to their unique properties and promising applications.
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Supramolecular hydrogels based on host–guest interactions have drawn considerable attention due to their unique properties and promising applications.
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Modulating neutrophil extracellular traps for wound healing
Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00355G, Paper
DOI: 10.1039/D0BM00355G, Paper
Tejinder Kaur, Shweta Dumoga, Veena Koul, Neetu Singh
An alginate-GelMa scaffold for modulating neutrophil extracellular traps using a PAD4 inhibitor could be a novel therapeutic approach for wound healing.
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An alginate-GelMa scaffold for modulating neutrophil extracellular traps using a PAD4 inhibitor could be a novel therapeutic approach for wound healing.
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A multifunctional metal-biopolymer coordinated double network hydrogel combined with multi-stimulus responsiveness, self-healing, shape memory and antibacterial properties
Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00425A, Paper
DOI: 10.1039/D0BM00425A, Paper
Kun Yan, Feiyang Xu, Chunyu Wang, Yingying Li, Yuanli Chen, Xiufang Li, Zhentan Lu, Dong Wang
A universal, straightforward macroscale assembly technology has been presented for fabrication of polysaccharide-based multifunctional DN gels based on metal coordination chemistry.
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A universal, straightforward macroscale assembly technology has been presented for fabrication of polysaccharide-based multifunctional DN gels based on metal coordination chemistry.
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Outstanding Reviewers for Biomaterials Science in 2019
Biomater. Sci., 2020, 8,2343-2343
DOI: 10.1039/D0BM90031A, Editorial
DOI: 10.1039/D0BM90031A, Editorial
We would like to take this opportunity to highlight the Outstanding Reviewers for Biomaterials Science in 2019, as selected by the editorial team for their significant contribution to the journal.
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An intelligent vancomycin release system for preventing surgical site infections of bone tissues
Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00255K, Paper
DOI: 10.1039/D0BM00255K, Paper
Yuan Li, Guang Li, Xiaoling Sha, Litao Li, Kuo Zhang, Daohong Liu, Yanfei Hao, Xu Cui, Lei Wang, Hao Wang
An intelligent anti-bacterial system can be constructed on implants during surgery.
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An intelligent anti-bacterial system can be constructed on implants during surgery.
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Particle-mediated delivery of frataxin plasmid to a human sensory neuronal model of Friedreich's ataxia
Biomater. Sci., 2020, 8,2398-2403
DOI: 10.1039/C9BM01757G, Communication
DOI: 10.1039/C9BM01757G, Communication
Ewa Czuba-Wojnilowicz, Serena Viventi, Sara E. Howden, Simon Maksour, Amy E. Hulme, Christina Cortez-Jugo, Mirella Dottori, Frank Caruso
Multilayered particles in gene therapy for Friedreich's ataxia induce a 27 000-fold increase in frataxin gene expression in a patient-derived cell model.
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Multilayered particles in gene therapy for Friedreich's ataxia induce a 27 000-fold increase in frataxin gene expression in a patient-derived cell model.
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A novel peptide targeting gastrin releasing peptide receptor for pancreatic neoplasm detection
Biomater. Sci., 2020, 8,2682-2693
DOI: 10.1039/D0BM00162G, Paper
DOI: 10.1039/D0BM00162G, Paper
Yuanbiao Tu, Ji Tao, Fang Wang, Peifei Liu, Zhihao Han, Zhaolun Li, Yi Ma, Yueqing Gu
The designed novel peptide GB-6 with targeted GRPR-binding possesses more favorable pharmacokinetic properties and metabolic stability, as well as superior tumor-targeting ability in pancreatic cancer models, relative to BBN7–14.
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The designed novel peptide GB-6 with targeted GRPR-binding possesses more favorable pharmacokinetic properties and metabolic stability, as well as superior tumor-targeting ability in pancreatic cancer models, relative to BBN7–14.
The content of this RSS Feed (c) The Royal Society of Chemistry
Interfacing human induced pluripotent stem cell-derived neurons with designed nanowire arrays as a future platform for medical applications
Biomater. Sci., 2020, 8,2434-2446
DOI: 10.1039/D0BM00182A, Paper
DOI: 10.1039/D0BM00182A, Paper
Jann Harberts, Undine Haferkamp, Stefanie Haugg, Cornelius Fendler, Dennis Lam, Robert Zierold, Ole Pless, Robert H. Blick
Nanostructured substrates such as nanowire arrays form a powerful tool for building next-generation medical devices.
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Nanostructured substrates such as nanowire arrays form a powerful tool for building next-generation medical devices.
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Advances in living cell-based anticancer therapeutics
Biomater. Sci., 2020, 8,2344-2365
DOI: 10.1039/D0BM00036A, Review Article
DOI: 10.1039/D0BM00036A, Review Article
He Dong, Xiao Xu, Leikun Wang, Ran Mo
This review summarizes recent advances in the applications of living cells as drug carriers or active drugs for anticancer drug delivery and cancer therapy.
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This review summarizes recent advances in the applications of living cells as drug carriers or active drugs for anticancer drug delivery and cancer therapy.
The content of this RSS Feed (c) The Royal Society of Chemistry
Biodegradable nanocomposite fibrous scaffold mediated local delivery of vancomycin for the treatment of MRSA infected experimental osteomyelitis
Biomater. Sci., 2020, 8,2653-2665
DOI: 10.1039/D0BM00140F, Paper
DOI: 10.1039/D0BM00140F, Paper
Amit G. Krishnan, Raja Biswas, Deepthy Menon, Manitha B. Nair
The study shows the development of a biodegradable bi-functional composite scaffold that can reduce bacterial infection, while promotes bone regeneration in osteomyelitis, without the need for revision surgery.
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The study shows the development of a biodegradable bi-functional composite scaffold that can reduce bacterial infection, while promotes bone regeneration in osteomyelitis, without the need for revision surgery.
The content of this RSS Feed (c) The Royal Society of Chemistry